Thousands of human mobile element fragments undergo strong purifying selection near developmental genes
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چکیده
منابع مشابه
Supplement: Thousands of human mobile element fragments undergo strong purifying selection near developmental genes
S1 pan-boreoeutherian mobile elements Mobile elements, as annotated by Repbase [1] and RepeatMasker [2], have a hierarchical naming convention where they are first broken down into classes, then families, and finally subfamilies. In the main text we define “pan-boreoeutherian” subfamilies to be the subfamilies that are present in primates (human, chimp, or rhesus), rodents (rat or mouse), and c...
متن کاملThousands of human mobile element fragments undergo strong purifying selection near developmental genes.
At least 5% of the human genome predating the mammalian radiation is thought to have evolved under purifying selection, yet protein-coding and related untranslated exons occupy at most 2% of the genome. Thus, the majority of conserved and, by extension, functional sequence in the human genome seems to be nonexonic. Recent work has highlighted a handful of cases where mobile element insertions h...
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To achieve dosage balance of X-linked genes between mammalian males and females, one female X chromosome becomes inactivated. However, approximately 15% of genes on this inactivated chromosome escape X chromosome inactivation (XCI). Here, using a chromosome-wide analysis of primate X-linked orthologs, we test a hypothesis that such genes evolve under a unique selective pressure. We find that es...
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There is an intense debate concerning whether selection or demographics has been most important in shaping the sequence variation observed in modern human mitochondrial DNA (mtDNA). Purifying selection is thought to be important in shaping mtDNA sequence evolution, but the strength of this selection has been debated, mainly due to the threshold effect of pathogenic mtDNA mutations and an observ...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2007
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0611223104