Three functional classes of transcriptional activation domain
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چکیده
منابع مشابه
Three Functional Classes of Transcriptional Activation Domains
JUSTIN BLAU,† HUA XIAO,† SUSAN MCCRACKEN, PETER O’HARE, JACK GREENBLATT, AND DAVID BENTLEY* Molecular Genetics of Differentiation Laboratory, Imperial Cancer Research Fund, London WC2A 3PX, and Marie Curie Research Institute, Oxted, Surrey RH8 0TL, United Kingdom, and Banting and Best Department of Medical Research and Department of Molecular and Medical Genetics, University of Toronto, Toronto...
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We have studied the ability of the wt1 tumor suppressor gene product to repress different classes of activation domains previously shown to stimulate the initiation and elongation steps of RNA polymerase II transcription in vivo. Repression assays revealed that WT1 represses all three classes of activation domains: Sp1 and CTF, which stimulate initiation (type I), human immunodeficiency virus t...
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Artificial transcriptional activators are excellent tools for studying the mechanistic details of transcriptional regulation. Furthermore, as the correlation between a wide range of human diseases and misregulated transcription becomes increasingly evident, such molecules may in the long run serve as the basis for transcription-based therapeutic agents. The greatest challenge in this arena has ...
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The ability of transcriptional activation domains (TADs) to signal ubiquitin-mediated proteolysis suggests an involvement of the ubiquitin-proteasome pathway in transcription. To probe this involvement, we asked how ubiquitylation regulates the activity of a transcription factor containing the VP16 TAD. We show that the VP16 TAD signals ubiquitylation through the Met30 ubiquitin-ligase and that...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 1996
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.16.5.2044