Thromboelastography parameters in diagnosing periprosthetic joint infection and predicting reimplantation timing
نویسندگان
چکیده
Abstract Background Coagulation-related biomarkers are drawing new attention in the diagnosis of periprosthetic joint infection (PJI). The thromboelastography (TEG) assay provides a comprehensive assessment blood coagulation; therefore, it could be promising test for PJI. This study aims to assess value TEG diagnosing PJI and determine clinical significance analysing reimplantation timing second-stage revision. Methods From October 2017 September 2020, 62 patients who underwent revision arthroplasty were prospectively included. was defined by 2011 Musculoskeletal Infection Society criteria, which 23 diagnosed with (Group A), remaining 39 included as having aseptic loosening B). In group A, 17 completed two-stage our centre. C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), D-dimer, parameters (clotting time, α-angle, MA [maximum amplitude], amplitude at 30 min, thrombodynamic potential index) measured preoperatively all patients. addition, receiver operating characteristic curves used evaluate diagnostic these biomarkers. Results ESR (area under curve [AUC], 0.953; sensitivity, 81.82; specificity, 94.87) performed best diagnosis, followed (AUC, 0.895; 82.61; 97.44) CRP 0.893; 94.74). When combined pairs, improved compared any individual biomarker. overall success 100%. Furthermore, valuable determining time reimplantation, their values decreased below cut-off before reimplantation. Conclusion assisting useful tool judging proper
منابع مشابه
Prevention of Periprosthetic Joint Infection
Prosthetic joint infection (PJI) is a calamitous complication with high morbidity and substantial cost. The reported incidence is low but it is probably underestimated due to the difficulty in diagnosis. PJI has challenged the orthopaedic community for several years and despite all the advances in this field, it is still a real concern with immense impact on patients, and the healthcare system....
متن کاملUnyvero i60 implant and tissue infection (ITI) multiplex PCR system in diagnosing periprosthetic joint infection.
Periprosthetic joint infection (PJI) is one of the most challenging complications in orthopedic surgery. In cases of suspected periprosthetic joint infection several diagnostic methods are available. In this study we investigated the performance of the newly available Unyvero i60 implant and tissue infection (ITI) multiplex PCR System. 62 specimens from 31 patients with suspected PJI or aseptic...
متن کاملprevention of periprosthetic joint infection
prosthetic joint infection (pji) is a calamitous complication with high morbidity and substantial cost. the reported incidence is low but it is probably underestimated due to the difficulty in diagnosis. pji has challenged the orthopaedic community for several years and despite all the advances in this field, it is still a real concern with immense impact on patients, and the healthcare system....
متن کاملPrevention of Periprosthetic Joint Infection
Prosthetic joint infection (PJI) is a calamitous complication with high morbidity and substantial cost. The reported incidence is low but it is probably underestimated due to the difficulty in diagnosis. PJI has challenged the orthopaedic community for several years and despite all the advances in this field, it is still a real concern with immense impact on patients, and the healthcare system....
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ژورنال
عنوان ژورنال: BMC Musculoskeletal Disorders
سال: 2021
ISSN: ['1471-2474']
DOI: https://doi.org/10.1186/s12891-021-04578-x