Time points and risk factors for RhD immunizations after the implementation of targeted routine antenatal anti?D prophylaxis: A retrospective nationwide cohort study

Introduction Targeted routine antenatal anti-D prophylaxis was introduced to the national program in Finland late 2013. The aim of this study assess incidence, time-points, and risk factors for Rhesus D immunization after implementation prophylaxis, all women with antibodies detected 2014–2017. Material methods In a nationwide population-based retrospective cohort study, immunizations were analyzed. Information on screening obtained from Finnish Red Cross Blood Service database, obstetric data hospital records Medical Birth Register. Results included total 228 (197 complete pregnancies). After prevalence pregnancies decreased 1.52% 2014 0.88% 2017, corresponding incidence new 0.33% 0.10%. Time-points detection before first sample at 8–12 weeks gestation 52% vs 19%, second 24–26 20% 50%, third 36 28% 32%. Conclusions as expected prophylaxis. True failures are rare they mainly occur when is not given appropriately, suggesting need constant education healthcare professionals subject.