Time Variability of C-Reactive Protein: Implications for Clinical Risk Stratification

Time Variability of C-Reactive Protein: Implications for Clinical Risk Stratification

BACKGROUND C-reactive protein (CRP) is proposed as a screening test for predicting risk and guiding preventive approaches in coronary artery disease (CAD). However, the stability of repeated CRP measurements over time in subjects with and without CAD is not well defined. We sought to determine the stability of serial CRP measurements in stable subjects with distinct CAD manifestations and a gro...

Implications of increased C-reactive protein for cardiovascular risk stratification in black and white men and women in the US.

BACKGROUND We evaluated prevalence and correlates of increased high-sensitivity C-reactive protein (hsCRP) in a large population of blacks and whites, and the impact of hsCRP measurement on coronary heart disease risk reclassification. METHODS We studied 19 080 participants of the REGARDS (REasons for Geographic And Racial Differences in Stroke) study (age >45 years, without vascular diagnose...

Predictive ability of C-reactive protein for stroke

Lipoprotein-associated phospholipase A2 and C-reactive protein for risk-stratification of patients with TIA.

BACKGROUND AND PURPOSE Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is a marker of unstable atherosclerotic plaque, and is predictive of both primary and secondary stroke in population-based studies. METHODS We conducted a prospective study of patients with acute TIA who presented to the ED. Clinical risk scoring using the ABCD(2) score was determined and Lp-PLA(2) mass (LpPLA(2)-M) ...

C-reactive protein as a clinical marker of risk.

To the Editor: We read with great interest the article by Lagrand et al1 in which the authors both review the role of C-reactive protein (CRP) as a marker of cardiovascular risk and propose a pathogenetic role for CRP. Although the evidence reviewed by Lagrand et al1 convincingly suggests an association between CRP and cardiovascular risk, we are concerned that the authors appear to assume that...