Timing urinary tract reconstruction in rats to avoid hydronephrosis and fibrosis in the transplanted fetal metanephros as assessed using imaging

نویسندگان

چکیده

Chronic kidney disease leads to high morbidity rates among humans. Kidney transplantation is often necessary for severe symptoms; however, options new curative treatments are desired because of donor shortage. For example, it has been established that the kidneys can efficiently generate urine after metanephros, ureter, and bladder as a group. After transplantation, indirectly flow into recipient’s using stepwise peristaltic ureter system method where anastomosis created via urinary tract reconstruction. However, growth regenerated metanephros varies significantly, whereas time window successful completion does not cause hydronephrosis with (ureter) quite narrow. Therefore, this study was conducted periodically noninvasively evaluate transplanted in rats through computed tomography ultrasonography. The ultrasonographic findings highly correlated clearly showed bladder. We found degree differed each case. Most were ready reconstruction within 21 days transplantation. Optimizing ultrasonography allowed interventions reduce long-term tubular dilation due inhibited overdilation fetal bladder, thereby decreasing fibrosis caused possibly by transforming factor-β1. These results may be significantly related maturation provide insights physiology transplant regeneration higher animals. Thus, contributes evidence base possibility human clinical trials.

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ژورنال

عنوان ژورنال: PLOS ONE

سال: 2021

ISSN: ['1932-6203']

DOI: https://doi.org/10.1371/journal.pone.0231233