Tissue Distribution of Human α1-Microglobulin
نویسندگان
چکیده
منابع مشابه
Increased levels of hemoglobin and α1-microglobulin in Huntington’s disease
1. Abstract 2. Introduction 3. Materials and methods 3.1. Collection and processing of human samples 3.2. Reagents and proteins 3.3. Determination of protein carbonyl groups 3.4. Radioimmunoassay 3.5. Hemoglobin measurement 3.6. Thiobarbituric acid-assay 3.7. Statistical analysis 4. Results 4.1. Analysis of urine samples in cohort 1 4.2. Analysis of urine samples in cohort 2 4.3. Plasma markers...
متن کاملCharacterization of heme binding to recombinant α1-microglobulin
BACKGROUND Alpha-1-microglobulin (A1M), a small lipocalin protein found in plasma and tissues, has been identified as a heme and radical scavenger that may participate in the mitigation of toxicities caused by degradation of hemoglobin. The objective of this work was to investigate heme interactions with A1M in vitro using various analytical techniques and to optimize analytical methodology sui...
متن کاملHuman 8 2 - microglobulin is a Substrate of Tissue
Incubation of purified human 82-microglobulin (B2-m) with tissue transglutaminase (Tgase) resulted in the formation of high molecular weight polymers revealed by sodium dodecyl sulfate polyacrylamide gel electrophoresis. In the presence of 30 mM ['4C]methylamine, the polymer formation was prevented, but incorporation of methylamine into ,8 2-m (equal to 1 methylamine per 1 molecule) could be ob...
متن کاملHuman tissue distribution of voriconazole.
Voriconazole concentrations were determined in autopsy samples of eight patients who had been treated for a median of 7 days (interquartile range [IQR], 5 days). Voriconazole penetrates well into various tissues, with median levels of 6.26 μg/g ((interquartile range [IQR], 7.87 μg/g) in the lung, 3.41 μg/g (IQR, 16.72 μg/g) in the brain, 6.89 μg/g (IQR, 24.16 μg/g) in the liver, 6.47 μg/g (IQR,...
متن کاملTissue Distribution of 125I-human Nonspecific Polyclonal IgG in Normal and Induced Inflammation Mice
Many different radiolabeled antibodies have been used for radioimmunotherapy and radioimmunoscintigraphy of human diseases in animal experiments. In order to study the in vivo tissue distribution of antibody, we labeled human nonspecific polyclonal IgG with Na125I using chloramine-T method. An animal model was developed by injecting turpentine in the posterior left thigh of Balb/c mice. Tissue ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1979
ISSN: 0021-9738
DOI: 10.1172/jci109305