TNFα and IL1β do not induce Langerhans cell migration by inhibiting TGFβ activation
نویسندگان
چکیده
منابع مشابه
Langerhans cells and the cells of Langerhans cell histiocytosis do not express DC-SIGN.
vasculitic lesions. Cell-mediated immune (CMI) dysfunction, including defective natural killer cell function has been documented in patients with XLP, and defective CMI may result in altered EBV tissue tropism as we suggest. We agree that many more patients, as well as controls, would need to be studied to definitively answer this issue. The functionality of EBV-specific CTL remains a subject f...
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OBJECTIVES To determine the mechanism underlying hypertrophic synovium in rheumatoid arthritis (RA). METHODS We examined micromass cultures of fibroblast-like synoviocytes (FLSs) stimulated with tumor necrosis factor α (TNFα), platelet-derived growth factor (PDGF), and/or transforming growth factor β (TGFβ). The hypertrophic architecture of the micromasses, expression of phosphoinositide 3 ki...
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Ying-Ping Xu1,2,4,5, Yuling Shi1,2, Zhi-Zhong Cui4, Hong H. Jiang6, Li Li6, Xiao-Fan Wang7, Li Zhou1,2,3, and Qing-Sheng Mi1,2,3 1Henry Ford Immunology Program, Henry Ford Hospital, Detroit, MI 2Department of Dermatology, Henry Ford Hospital, Detroit, MI 3Department of Internal Medicine, Henry Ford Hospital, Detroit, MI 4Department of Preventive Veterinary Medicine, College of Animal Science an...
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Saussurea lappa Clarke (SLC) has been used as a traditional medicine in Korea, China, and Japan for the treatment of abdominal pain and tenesmus. Costunolide, a sesquiterpene lactone isolated from SLC, has diverse medicinal effects. However, the anticancer effects of costunolide are still unclear in breast cancer. In this study, we demonstrate that costunolide suppresses tumor growth and metast...
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TNFalpha is a pleiotropic cytokine that induces either cell proliferation or cell death. Inhibition of NF-kappaB activation increases susceptibility to TNFalpha-induced death, concurrent with sustained JNK activation, an important contributor to the death response. Sustained JNK activation in NF-kappaB-deficient cells was suggested to depend on reactive oxygen species (ROS), but how ROS affect ...
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ژورنال
عنوان ژورنال: JID Innovations
سال: 2021
ISSN: 2667-0267
DOI: 10.1016/j.xjidi.2021.100028