Tocilizumab Significantly Decreases Reactive Oxygen Species Level in Patients with Rheumatoid Arthritis
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چکیده
منابع مشابه
Cutaneous manifestations in patients with rheumatoid arthritis
Rheumatoid arthritis (RA) is a chronic inflammatory joint disease with different extra-articular manifestations. Among those extra-articular manifestations, there are significant cutaneous manifestations which may result in first admission to a dermatologist. In this article some specific and non-specific skin lesions of RA such as rheumatoid nodules, exacerbated nodules, rheumatoid vascu...
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Background: Previous studies showed that one of the complications of rheumatoid arthritis disease was auditory disorder. The goal of the present study was to compare the auditory status in patients with rheumatoid arthritis and healthy individuals. Methods: In the present case-control study, 30 normal persons and 60 persons with rheumatoid arthritis with mean age of 46.72 and standard deviatio...
متن کاملLevel of inflammatory cytokines in rheumatoid arthritis patients: Correlation with 25-hydroxy vitamin D and reactive oxygen species
BACKGROUND Rheumatoid arthritis (RA) is an autoimmune inflammatory disorder. Reactive oxygen species (ROS) and pro-inflammatory cytokines have been believed to be involved in the etiopathogenesis of the disease. The aim of the study was to determine the correlation of inflammatory cytokines with 25-hydroxy vitamin D and ROS. METHODS 100 RA patients and 50 healthy age and sex matched individua...
متن کاملMalignancy rates in patients with rheumatoid arthritis treated with tocilizumab
OBJECTIVE To analyse malignancy rates in patients with rheumatoid arthritis (RA) treated with tocilizumab. METHODS Patients who received tocilizumab or placebo+methotrexate/disease-modifying antirheumatic drugs in the double-blind phases of 5-phase three trials or who received at least 1 dose of tocilizumab in the long-term extension studies were analysed up to the 2 May 2012 cut-off date. Ma...
متن کاملthe role of reactive oxygen species in immunopathogenesis of rheumatoid arthritis
rheumatoid arthritis is a disease associated with painful joints that affects approximately 1% of the population worldwide, and for which no effective cure is available. it is characterized by chronic joint inflammation and variable degrees of bone and cartilage erosion. oxygen metabolism has an important role in the pathogenesis of rheumatoid arthritis. reactive oxygen species (ros) are produc...
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ژورنال
عنوان ژورنال: Open Journal of Rheumatology and Autoimmune Diseases
سال: 2017
ISSN: 2163-9914,2164-005X
DOI: 10.4236/ojra.2017.71004