Tooth shape formation and tooth renewal: evolving with the same signals
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چکیده
منابع مشابه
Tooth shape formation and tooth renewal: evolving with the same signals.
Teeth are found in almost all vertebrates, and they therefore provide a general paradigm for the study of epithelial organ development and evolution. Here, we review the developmental mechanisms underlying changes in tooth complexity and tooth renewal during evolution, focusing on recent studies of fish, reptiles and mammals. Mammals differ from other living vertebrates in that they have the mo...
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Previous studies have suggested that Bmp4 is a key Msx1-dependent mesenchymal odontogenic signal for driving tooth morphogenesis through the bud-to-cap transition. Whereas all tooth germs were arrested at the bud stage in Msx1(-/-) mice, we show that depleting functional Bmp4 mRNAs in the tooth mesenchyme, through neural crest-specific gene inactivation in Bmp4(f/f);Wnt1Cre mice, caused mandibu...
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One of the most reasonable hypotheses regarding the functional significance of the browridge is that the supraorbital torus forms in response to masticatory stress during development. Oyen, Walker, and Rice (1979) have recently proposed a model that tests this hypothesis: if browridges are functionally related to masticatory stresses on the cranial vault, then changes in the biomechanics of the...
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ژورنال
عنوان ژورنال: Development
سال: 2012
ISSN: 1477-9129,0950-1991
DOI: 10.1242/dev.085084