Topical application of laminin-332 to diabetic mouse wounds
نویسندگان
چکیده
منابع مشابه
Laminin 332 processing impacts cellular behavior
Laminin 332, composed of the α3, β3 and γ2 chains, is an epithelial-basement membrane specific laminin variant. Its main role in normal tissues is the maintenance of epithelial-mesenchymal cohesion in tissues exposed to external forces, including skin and stratified squamous mucosa. After being secreted and deposited in the extracellular matrix, laminin 332 undergoes physiological maturation pr...
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Introduction: Among the components of the extracellular matrix (ECM) and basement membrane (BM), laminitis heterotrimeric glycoprotein (laminin) and collagen type IV are the most important. In a previous study we have examined the role of collagen type IV in the developing lens capsule. The present study aims to determine the appearance and distribution of laminin in the BM and ECM of lenses ...
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Wounds are a major cause of morbidity especially diabetic foot wounds. Topical antimicrobials are frequently used in day to day practice mainly in management of wounds by various healthcare professionals ranging from general practitioner to specialist surgeons. However lot of controversies exists regarding the usage of antimicrobials. This article provides an insight on the usage of various com...
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Laminin 511 Partners with Laminin 332 to Mediate Directional Migration of Madin-Darby Canine Kidney (MDCK) Epithelial Cells Patricia G. Greciano, Jose V. Moyano, Mary M. Buschmann, Jun Tang, Yue Lu, Jean Rudnicki , Aki Manninen, and Karl S. Matlin Department of Surgery and Committee on Molecular Medicine, The University of Chicago, Chicago, Illinois 60637, USA Department of Pathology, The Unive...
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Epidermal wound repair is a complex process involving the fine orchestrated regulation of crucial cell functions, such as proliferation, adhesion and migration. Using an in vitro model that recapitulates central aspects of epidermal wound healing, we demonstrate that the transcription factor HIF1 is strongly stimulated in keratinocyte cultures submitted to mechanical injury. Signals generated b...
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ژورنال
عنوان ژورنال: Journal of Dermatological Science
سال: 2007
ISSN: 0923-1811
DOI: 10.1016/j.jdermsci.2007.07.002