Total Synthesis, Stereochemical Reassignment, and Absolute Configuration of Chlorofusin
نویسندگان
چکیده
منابع مشابه
Total synthesis, stereochemical reassignment, and absolute configuration of chlorofusin.
Chlorofusin (1, Figure 1A) was isolated from the fungal strain Microdochium caespitosum and found to disrupt the MDM2-p53 interaction by binding to the N-terminal domain of MDM2.1 As such, chlorofusin represents an exciting lead for antineoplastic intervention that acts by a rare disruption of a protein-protein interaction.2 On the basis of spectroscopic and degradation studies, the structure w...
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The total synthesis of the tunicate metabolite mandelalide A and the correction of its originally assigned stereochemistry are reported. Key features of the convergent, fully stereocontrolled route include the use of a Prins cyclization for the diastereoselective construction of the tetrahydropyran subunit, Rychnovsky-Bartlett cyclization for the preparation of the tetrahydrofuran moiety, Suzuk...
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(-)-Lyngbyaloside B is a 14-membered macrolide glycoside isolated from the marine cyanobacterium Lyngbya sp. as a cytotoxic substance by Moore and co-workers. The first total synthesis of (-)-lyngbyaloside B and the reassignment of its stereostructure is described. The synthesis features an Abiko-Masamune aldol reaction, a vinylogous Mukaiyama aldol reaction, and a macrocyclization involving an...
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ژورنال
عنوان ژورنال: Journal of the American Chemical Society
سال: 2007
ISSN: 0002-7863,1520-5126
DOI: 10.1021/ja073264v