Toward trustworthy, useful and independent guidelines — acknowledging conflicts when they exist

Primordial Black Holes: Do They Exist and Are They Useful?

Recent developments in the study of primordial black holes (PBHs) are reviewed, with particular emphasis on their formation and evaporation. It is still not clear whether PBHs formed but, if they did, they could provide a unique probe of the early Universe, gravitational collapse, high energy physics and quantum gravity. Indeed their study may place interesting constraints on the physics releva...

New cardiovascular risk factors exist, but are they clinically useful?

There is substantial interest in identifying new risk factors for cardiovascular disease, to improve our understanding of disease biology and to account for the cases of heart disease that cannot be explained by known risk factors. Investigation of putative risk factors frequently involves the study of circulating biomarkers. In recent years, a spirited debate has arisen regarding the validity ...

Attitudes toward computers: when do they predict computer use?

Many people in the MIS ®eld have accepted the idea that attitudes affect the frequency and type of computer use but research has provided inconsistent results. This paper, therefore, explores the conditions under which attitudes can predict computer use, investigating both workers' volitional control and their knowledge of the technology. Analyses are based on responses of 168 white-collar empl...

Evidence, experts, trustworthy guidelines and WikiRecs.

Clinical practice guidelines, based on the concept of evidence-based medicine, have positively impacted care of patients with cardiovascular disease, since their introduction over 30 years ago. Guidelines both ‘guide’ clinical practice and inform national and local healthcare policy. Now, a new definition for trustworthy guidelines —supported by explicit standards—is a major advance widely reco...

too many students’ congresses, are they necessary and useful?