Towards a general model for protein-substrate stereoselectivity
نویسندگان
چکیده
منابع مشابه
Towards a general model for protein-substrate stereoselectivity.
Protein-substrate interactions in enzymatic, neurological, and immunological systems are typically characterized by a high degree of stereoselectivity towards complex substrates. We propose a novel stereocenter-recognition (SR) model for stereoselectivity of proteins (or receptors in general) towards substrates that have multiple stereocenters, based on the topology of substrate stereocenters. ...
متن کاملTowards a General Model for Linguistic Paradigms
Linguistic forms are inherently multi-dimensional. They exhibit a variety of phonological, orthographic, morphosyntactic, semantic and pragmatic properties. Accordingly, linguistic analysis involves multi-dimensional exploration, a process in which the same collection of forms are laid out in many ways until clear patterns emerge. Equally, language documentation usually contains tabulations of ...
متن کاملTowards a General Model for Argumentation Services
LA is a formal Logic of Argument which was originally developed as a flexible foundation for knowledge-level decision models, and to facilitate explanation and userinterface design. The logic has a clear semantics and is embodied in the PROforma language, a simple but effective representation for modeling decisions, plans and software agents. ASPIC is an EU funded project1 that aims to develop ...
متن کاملMolecular basis for the substrate stereoselectivity in tryptophan dioxygenase.
Tryptophan dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO) are the only two heme proteins that catalyze the oxidation reaction of tryptophan (Trp) to N-formylkynurenine. While human IDO is able to oxidize both L- and D-Trp, human TDO (hTDO) displays major specificity for L-Trp. In this work, we aim to interrogate the molecular basis for the substrate stereoselectivity of hTDO. Our previ...
متن کاملinvestigating the feasibility of a proposed model for geometric design of deployable arch structures
deployable scissor type structures are composed of the so-called scissor-like elements (sles), which are connected to each other at an intermediate point through a pivotal connection and allow them to be folded into a compact bundle for storage or transport. several sles are connected to each other in order to form units with regular polygonal plan views. the sides and radii of the polygons are...
ذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Protein Science
سال: 2002
ISSN: 0961-8368,1469-896X
DOI: 10.1110/ps.3280102