Towards tumor therapy with interferons, Part I. Interferons: production and properties
نویسندگان
چکیده
منابع مشابه
Towards tumor therapy with interferons, Part I. Interferons: production and properties.
I NTERFERONS are a family of inducible secretory glycoproteins produced by eukaryotic cells in response to viral infections or other stimuli. They are intercellular messages which, upon binding to specific cell surface receptors, direct cells to express a new, interferon-induced, phenotype. They have, therefore, aptly been called “inducible inducers.” Characteristically, all interferons induce ...
متن کاملTowards tumor therapy with interferons, part II. Interferons: in vivo effects.
PHARMACOLOGY AND TOXICOLOGY T HE PHARMACOLOGY of interferons has been studied with human leukocyte interferon and with mouse and rabbit interferons. These have a short half-life in the blood, irrespective of the route of administration, though the most rapid clearance follows the intravenous route; intramuscular injections result in peak blood levels after 2-4 hr, lasting for 4-6 hr. With intra...
متن کاملProduction of type I interferons
Plasmacytoid dendritic cells (pDCs) are specialized producers of type I interferons (IFNs) that respond to most viruses. Because of their antiviral activity and regulatory functions in innate and adaptive immunity, type I IFNs are important not only for antiviral resistance but also in other types of infections and in immune pathology. Here we discuss recent data that begin to reveal the unique...
متن کامل“Toll-free” pathways for production of type I interferons
Pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) are recognized by different cellular pathogen recognition receptors (PRRs), which are expressed on cell membrane or in the cytoplasm of cells of the innate immune system. Nucleic acids derived from pathogens or from certain cellular conditions represent a large category of PAMPs/DAMPs that trigger pr...
متن کاملInterferons
nterferons, naturally occuring glycoproteins with molecular weights of approximately 20,000 daltons, possess antiviral, antiproliferative, and immune-stimulating properties. They are classified into 3 antigenically distinct forms that are derived from different cell types. Alpha (or) interferons are derived from leukocytes, beta ([3) interferons from fibroblasts, and gamma (/) interferons from ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Blood
سال: 1980
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v55.5.711.711