Toxicovenomics and antivenom profiling of the Eastern green mamba snake ( Dendroaspis angusticeps )
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منابع مشابه
Toxicovenomics and antivenom profiling of the Eastern green mamba snake (Dendroaspis angusticeps).
UNLABELLED A toxicovenomic study was performed on the venom of the green mamba, Dendroaspis angusticeps. Forty-two different proteins were identified in the venom of D. angusticeps, in addition to the nucleoside adenosine. The most abundant proteins belong to the three-finger toxin (3FTx) (69.2%) and the Kunitz-type proteinase inhibitor (16.3%) families. Several sub-subfamilies of the 3FTxs wer...
متن کاملToxicovenomics and antivenom profiling of the Eastern green mamba
32 A toxicovenomic study was performed on the venom of the green mamba, 33 Dendroaspis angusticeps. Forty-two different proteins were identified in the venom of 34 D. angusticeps, in addition to the nucleoside adenosine. The most abundant proteins 35 belong to the three-finger toxin (3FTx) (69.2%) and the Kunitz-type proteinase inhibitor 36 (16.3%) families. Several sub-subfamilies of the 3FTxs...
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A blocker of postsynaptic acetylcholine receptors was isolated from venom of the Eastern green mamba Dendroaspis angusticeps, by gel filtration, ion-exchange and reverse phase high performance liquid chromatography. The isolated component blocks neuromuscular transmission and responses to exogenously applied acetylcholine in isolated chick biventer cervices preparations. These results suggest t...
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A blocker of postsynaptic acetylcholine receptors was isolated from venom of the Eastern green mamba Dendroaspis angusticeps, by gel filtration, ion-exchange and reverse phase high performance liquid chromatography. The isolated component blocks neuromuscular transmission and responses to exogenously applied acetylcholine in isolated chick biventer cervices preparations. These results suggest t...
متن کاملPeptides with in vitro anti-tumor activity from the venom of the Eastern green mamba, Dendroaspis angusticeps (Elapidae)
Two structurally related (48.6% amino acid sequence identity) peptides with cytotoxic activity against human non-small cell lung adenocarcinoma A549 cells were purified from the venom of the Eastern green mamba Dendroaspis angusticeps using reversed phase HPLC. The peptides were identified as members of the three-finger superfamily of snake toxins by mass fingerprinting of tryptic digests. The ...
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ژورنال
عنوان ژورنال: Journal of Proteomics
سال: 2016
ISSN: 1874-3919
DOI: 10.1016/j.jprot.2016.02.003