TOXIN-ANTITOXIN IMMUNIZATION AGAINST DIPHTHERIA
نویسندگان
چکیده
منابع مشابه
Antigenic relationships on the diphtheria toxin molecule: antitoxin versus antitoxoid.
We used the mouse to produce antisera to native diphtheria toxin and diphtheria toxoid. With these antisera it was possible to distinguish between toxin and toxoid. By gel diffusion analysis, antitoxin detected antigenic determinants on toxin which were not available on toxoid, indicating that some determinants had been lost or altered by formalin treatment. Antitoxoid, on the other hand, showe...
متن کاملTowards a recombinant vaccine against diphtheria toxin.
Two recombinant fragments of diphtheria toxin (DT) were fused to an engineered tandem repeat of the immunoglobulin (Ig) binding domain of protein A, called ZZ. These fragments are (i) the receptor binding domain (DTR), which comprises amino acids 382 to 535 of DT, and (ii) a linear peptide (DT(168-220)) which comprises residues 168 to 220 of the loop between fragment A and fragment B of DT. The...
متن کاملDiphtheria Immunization *
AT the beginning of the twentieth century diphtheria occupied a unique position in contrast to other infectious diseases. Its symptoms and course were well known and accurately described, the causal organism definitely recognized, and a specific remedy was available for its treatment, yet in spite of this wealth of scientific knowledge the control and prevention of the disease had proved a comp...
متن کاملStudies on the Molecular Weight of Diphtheria Toxin, Antitoxin, and Their Reaction Products
Purified diphtheria antitoxic horse pseudoglobulin has been prepared which is homogeneous by sedimentation, diffusion, and electrophoresis. Immunologically, however, the preparation contains only 43.5 per cent antitoxin specifically precipitable by toxin. The inactive pseudoglobulin remaining after specific precipitation was found to have the same physical and chemical properties as the origina...
متن کاملActive Immunity Produced by so Called Balanced or Neutral Mixtures of Diphtheria Toxin and Antitoxin
The foregoing and earlier data taken together demonstrate that an active immunity lasting several years can be produced in guinea-pigs, by the injection of toxin-antitoxin mixtures which have no recognizable harmful effect either immediate or remote. They also show, what might have been anticipated, that under the same conditions mixtures which produce local lesions and which, therefore, contai...
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ژورنال
عنوان ژورنال: JAMA: The Journal of the American Medical Association
سال: 1922
ISSN: 0098-7484
DOI: 10.1001/jama.1922.02640190022009