TP1.2.6Functional Outcomes of Organ Preservation Strategies - Local Excision Procedures and 'Watchful-Waiting' In Management of Low Rectal Cancers - A Systematic Review

Abstract Objective To evaluate functional outcomes and quality of life (QOL) associated with `wait-and-watch’ (WW) strategy local-excision (LE) rectal tumours after neo-adjuvant therapy, in comparison to the standard practice total-mesorectal-excision (TME) for locally-advanced-rectal-cancers. Data Sources Medline, EMBASE, PubMed databases, sources Grey literature. Study Selection Randomised non-randomised prospective studies, retrospective studies propensity-score-matched analyses analysing WW LE procedures cancer. Extraction Synthesis Risk bias assessments data extraction were carried out independently by two reviewers. A narrative synthesis was presented keeping 27-item PRISMA checklist. Main Outcomes The interest those faecal-incontinence (FI), bowel rectal-evacuatory function, sexual-function, stoma-free-survival, quality-of-life scores, which assessed radical surgeries. Results 7 reported outcomes. Faecal-incontinence, bowel, rectal-evacuatory-function various scoring systems found be least affected among patients on strategy, followed undergoing local excision most TME. These reflected (FIQOL FACT-C questionnaires). Sexual dysfunction not higher who underwent compared Advantage stoma-free-survival organ preservation strategies realised up 2 years treatment. Conclusions Organ-preservation appear have a favourable outcome gold TME commencement Further research is warranted provide stronger levels evidence regarding same.