Tracing the hemangioblast during embryogenesis: developmental relationships between endothelial and hematopoietic cells

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Tracing the hemangioblast during embryogenesis: developmental relationships between endothelial and hematopoietic cells.

We review here the development of the hematopoietic system and its relationship to the endothelium, with a special focus on the characterisation of the hemangioblast, the putative ancestor for endothelial cells and hematopoietic cells. Using the avian model, we have traced in vivo the progeny of embryonic endothelial cells and shown that aortic-born hematopoietic cells (known to generate the de...

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Hematopoietic stem cells (HSCs) originate within the aortic-gonado-mesonephros (AGM) region of the midgestation embryo, but the cell type responsible for their emergence is unknown since critical hematopoietic factors are expressed in both the AGM endothelium and its underlying mesenchyme. Here we employ a temporally restricted genetic tracing strategy to selectively label the endothelium, and ...

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ژورنال

عنوان ژورنال: The International Journal of Developmental Biology

سال: 2005

ISSN: 0214-6282

DOI: 10.1387/ijdb.041948tj