Track structure model for damage to mammalian cell cultures during solar proton events

Track structure model for damage to mammalian cell cultures during solar proton events.

Solar proton events (SPEs) occur infrequently and unpredictably, thus representing a potential hazard to interplanetary space missions. Biological damage from SPEs will be produced principally through secondary electron production in tissue, including important contributions due to delta rays from nuclear reaction products. We review methods for estimating the biological effectiveness of SPEs...

Polar Mesosphere Winter Echoes during Solar Proton Events

Thin layers of enhanced radar echoes in the winter mesosphere have been observed by the ESRAD 52 MHz MST radar (67° 53 ‘ N, 21 ° 06 ‘ E) during several recent solar proton events. These polar mesosphere winter echoes (PMWE) can occur at any time of day or night above 70 km altitude, whereas below this height they are seen only during daytime. An energy deposition / ion-chemical model is used to...

Oxidative stress on mammalian cell cultures during recombinant protein expression

When the cell is under stress arising from oxidation, heat, infection, toxic contamination or any other stressful condition, proteins may unfold and expose residues in their structure that under normal physiological conditions are hidden and shielded from chemical reactions. In this licentiate thesis the effects of general oxidative stress on the production of recombinant protein by mammalian c...

Mammalian cell cultures for biologics manufacturing.

Biopharmaceuticals represent a growing sector of the pharmaceutical industry, and are used for a wide range of indications, including oncology and rheumatology. Cultured mammalian cells have become the predominant expression system for their production, partly due to their ability to complete the posttranslational modifications required for drug safety and efficacy. Over the past decade, the pr...

Radiation track and DNA damage