Transdetermination: A New Trend in Cellular Reprogramming

I-10: Transcriptomics in Oocyte Mediated Cellular Reprogramming

a:4:{s:10:"Background";s:1707:"Early embryonic development in mammals begins in transcriptional silence with an oocyte-mediated transcriptional reprogramming of parental gametes occurs during a so called across-the-board process of “erase-and-rebuild”. In this process, the parental transcription programs are erased long before (maternal) or soon thereafter (paternal) fertilization to generate a...

Cellular reprogramming: a new avenue to cardiac regeneration?

Cellular reprogramming: a new approach to modelling Parkinson's disease.

iPSCs (induced pluripotent stem cells) offer an unparalleled opportunity to generate and study physiologically relevant cell types in culture. iPSCs can be generated by reprogramming almost any somatic cell type using pluripotency factors such as Oct4, SOX2, Nanog and Klf4. By reprogramming cells from patients carrying disease-associated mutations, and subsequent differentiation into the cell t...

EDITORIAL - A new trend to Rehabilitation

Current understanding of disability and impairment has led to new approaches in Rehabilitation. In this issue of Iranian Rehabilitation Journal, a variety of articles introduces a new trend in rehabilitation. "Emotion pitch" of each vowel sound and Percentage of vowel correct is the subject which Talie Zarifian and her colleagues discussed in their article. Persian speaking children can get ben...

Transcriptional reprogramming in cellular quiescence

Most cells in nature are not actively dividing, yet are able to return to the cell cycle given the appropriate environmental signals. There is now ample evidence that quiescent G0 cells are not shut-down but still metabolically and transcriptionally active. Quiescent cells must maintain a basal transcriptional capacity to maintain transcripts and proteins necessary for survival. This implies a ...