Transdifferentiation of hepatocytes to biliary epithelial cells requires expression of reprogramming factor Oct3/4 (398.8)
نویسندگان
چکیده
منابع مشابه
Transdifferentiation of epithelial glomerular cells.
Cell transdifferentiation is characterized by loss of some phenotypes along with acquisition of new phenotypes in differentiated cells. Differentiated cells are endowed with the capacity of transforming into cells of a different type having other functions (1,2). Gene expression in differentiated cells has long been considered an irreversible phenomenon that is established at the time of replic...
متن کاملExpression of hepatocytic- and biliary-specific transcription factors in regenerating bile ducts during hepatocyte-to-biliary epithelial cell transdifferentiation
BACKGROUND Under compromised biliary regeneration, transdifferentiation of hepatocytes into biliary epithelial cells (BEC) has been previously observed in rats, upon exposure to BEC-specific toxicant methylene dianiline (DAPM) followed by bile duct ligation (BDL), and in patients with chronic biliary liver disease. However, mechanisms promoting such transdifferentiation are not fully understood...
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15 صفحه اولHepatocyte Nucear Factor (hnf)-4α Induces Transdifferentiation of Hematopoietic Cells into Hepatocytes
Satish Khurana, Amit K Jaiswal and Asok Mukhopadhyay Stem Cell Biology Laboratory From National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi-110067, India. Current address: Stem Cell Institute, Katholieke University, Leuven, Belgium. Running head: HNF4α in hepatic differentiation Address correspondence to: Asok Mukhopadhyay, Ph.D., Stem Cell Biology Laboratory, National Institute of ...
متن کاملGlutathione depletion exacerbates methylenedianiline toxicity to biliary epithelial cells and hepatocytes in rats.
Methylenedianiline (DAPM) initially injures epithelial cells of major bile ducts, which is followed by cholestasis, cholangitis, and hepatocellular damage. This pattern of biliary injury resembles that produced by alpha-naphthylisothiocyanate (ANIT), a classic bile duct toxicant. Our goal was to determine whether prior depletion of hepatic total glutathione (GSx), a condition reported to protec...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2014
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.28.1_supplement.398.8