Transgenerational inheritance: Models and mechanisms of non-DNA sequence-based inheritance
نویسندگان
چکیده
منابع مشابه
Transgenerational Epigenetic Inheritance: Myths and Mechanisms
Since the human genome was sequenced, the term "epigenetics" is increasingly being associated with the hope that we are more than just the sum of our genes. Might what we eat, the air we breathe, or even the emotions we feel influence not only our genes but those of descendants? The environment can certainly influence gene expression and can lead to disease, but transgenerational consequences a...
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Inheritance of non-genetic factors permits ancestral environmental history to inform the development of subsequent generations. This form of soft inheritance has been shown in mammals, yet the molecular underpinnings of this phenomenon are poorly understood. In the present article, we focus on gametic inheritance of non-genetic factors, utilizing examples of paternal transmission to explore the...
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That there is a heritable or familial component of susceptibility to chronic non-communicable diseases such as type 2 diabetes, obesity and cardiovascular disease is well established, but there is increasing evidence that some elements of such heritability are transmitted non-genomically and that the processes whereby environmental influences act during early development to shape disease risk i...
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Reversible changes in gene expression independent of the genetic code can be transmitted from one generation to the next via poorly understood mechanisms. In worms, a histone-modifying enzyme is necessary to keep small RNA-guided transgenerational gene silencing in check.
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Recent fi ndings in the emerging fi eld of transgenerational epigenetic inheritance suggest that the lifestyle choices and experiences of an individual have biological implications for offspring not yet conceived. Studies show that diet, drugs, and even social experiences can lead to life-long changes in gene expression. Some changes in gene expression are passed down to future generations. The...
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ژورنال
عنوان ژورنال: Science
سال: 2016
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.aaf4945