Translational control by heme-regulated eIF2α kinase during erythropoiesis
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چکیده
منابع مشابه
Heme-regulated eIF2α kinase activated Atf4 signaling pathway in oxidative stress and erythropoiesis.
Heme-regulated eIF2α kinase (Hri) is necessary for balanced synthesis of heme and globin. In addition, Hri deficiency exacerbates the phenotypic severity of β-thalassemia intermedia in mice. Activation of Hri during heme deficiency and in β-thalassemia increases eIF2α phosphorylation and inhibits globin translation. Under endoplasmic reticulum stress and nutrient starvation, eIF2α phosphorylati...
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ژورنال
عنوان ژورنال: Current Opinion in Hematology
سال: 2014
ISSN: 1065-6251
DOI: 10.1097/moh.0000000000000030