Translational Control by the Eukaryotic Ribosome
نویسندگان
چکیده
منابع مشابه
Translational Control by the Eukaryotic Ribosome
The ribosome plays a universally conserved role in catalyzing protein synthesis. Kondrashov et al. (2011) now provide evidence that the loss of function of ribosomal protein L38 in mice leads to a selective reduction in the translation of Hox mRNAs, thus suggesting that ribosomal proteins play a critical role during embryonic development.
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Translation of an mRNA is generally divided into three stages: initiation, elongation and termination. The relative rates of these steps determine both the number and position of ribosomes along the mRNA, but traditional velocity sedimentation assays for the translational status of mRNA determine only the number of bound ribosomes. We developed a procedure, termed Ribosome Density Mapping (RDM)...
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15 صفحه اولThe Eukaryotic Ribosome MOLECULAR BIOLOGY
The past decade has seen a remarkable advance in our understanding of ribosomes, the large protein-RNA machines in all cells that use genetic information to synthesize proteins in a process known as translation. Ribosomes from all species consist of two subunits: a small subunit that decodes messenger RNA (mRNA), and a large subunit that catalyzes peptide bond formation between the growing poly...
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Despite the emergence of a large number of X-ray crystallographic models of the bacterial 70S ribosome over the past decade, an accurate atomic model of the eukaryotic 80S ribosome is still not available. Eukaryotic ribosomes possess more ribosomal proteins and ribosomal RNA than do bacterial ribosomes, which are implicated in extraribosomal functions in the eukaryotic cells. By combining cryo-...
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ژورنال
عنوان ژورنال: Cell
سال: 2011
ISSN: 0092-8674
DOI: 10.1016/j.cell.2011.04.006