Translational Control in Spermatogenesis
نویسندگان
چکیده
منابع مشابه
Haploid accumulation and translational control of phosphoglycerate kinase-2 messenger RNA during mouse spermatogenesis.
The intracellular location of the mRNA for the testis-specific isozyme of phosphoglycerate kinase-2 (PGK-2) has been determined for two spermatogenic cell types. The mRNA activity for PGK-2 from the polysomal and nonpolysomal fractions of pachytene primary spermatocytes or round spermatids has been assayed by cell-free translation with the polypeptide products monitored by immunoprecipitation, ...
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Translational Control in Myeloid Disease
Over the years a wealth of information on the role played by transcription factors in myeloid biology has contributed to our understanding of both normal and abnormal myeloid development. However, the regulation of mRNA translation in myeloid cell maturation has, in comparison, been a neglected area of study. A better understanding of the translational control of myeloid gene expression will un...
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The link between perturbations in translational control and cancer etiology is becoming a primary focus in cancer research. It has now been established that genetic alterations in several components of the translational apparatus underlie spontaneous cancers as well as an entire class of inherited syndromes known as "ribosomopathies" associated with increased cancer susceptibility. These discov...
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Translational control of specific mRNAs is a widespread mechanism of gene regulation, and it is especially important in pattern formation in the oocytes of organisms in which the embryonic axes are established maternally. Drosophila and Xenopus have been especially valuable in elucidating the relevant molecular mechanisms. Here, we comprehensively review what is known about translational contro...
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ژورنال
عنوان ژورنال: Developmental Biology
سال: 1995
ISSN: 0012-1606
DOI: 10.1006/dbio.1995.8049