Translational control of Nrf2 within the open reading frame
نویسندگان
چکیده
منابع مشابه
How translational accuracy influences reading frame maintenance.
Most missense errors have little effect on protein function, since they only exchange one amino acid for another. However, processivity errors, frameshifting or premature termination result in a synthesis of an incomplete peptide. There may be a connection between missense and processivity errors, since processivity errors now appear to result from a second error occurring after recruitment of ...
متن کاملOpen reading frame cloning: identification, cloning, and expression of open reading frame DNA.
A plasmid was constructed that facilitates the cloning and expression of open reading frame DNA. A DNA fragment containing a bacterial promoter and the amino terminus of the cI gene of bacteriophage lambda was fused to an amino-terminally deleted version of the lacZ gene. An appropriate cloning site was inserted between these two fragments such that a frameshift mutation was introduced upstream...
متن کاملTranslational Control via Protein-Regulated Upstream Open Reading Frames
Analysis of the regulation of msl-2 mRNA by Sex lethal (SXL), which is critical for dosage compensation in Drosophila, has uncovered a mode of translational control based on common 5' untranslated region elements, upstream open reading frames (uORFs), and interaction sites for RNA-binding proteins. We show that SXL binding downstream of a short uORF imposes a strong negative effect on major rea...
متن کاملA profusion of upstream open reading frame mechanisms in polyamine-responsive translational regulation
In many eukaryotic mRNAs one or more short 'upstream' open reading frames, uORFs, precede the initiator of the main coding sequence. Upstream ORFs are functionally diverse as illustrated by their variety of features in polyamine pathway biosynthetic mRNAs. Their propensity to act as sensors for regulatory circuits and to amplify the signals likely explains their occurrence in most polyamine pat...
متن کاملSURVEY AND SUMMARY A profusion of upstream open reading frame mechanisms in polyamine-responsive translational regulation
In many eukaryotic mRNAs one or more short ‘upstream’ open reading frames, uORFs, precede the initiator of the main coding sequence. Upstream ORFs are functionally diverse as illustrated by their variety of features in polyamine pathway biosynthetic mRNAs. Their propensity to act as sensors for regulatory circuits and to amplify the signals likely explains their occurrence in most polyamine pat...
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ژورنال
عنوان ژورنال: Biochemical and Biophysical Research Communications
سال: 2013
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2013.06.052