Transmission of trisomy decreases with maternal age in mouse models of Down syndrome, mirroring a phenomenon in human Down syndrome mothers
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چکیده
منابع مشابه
Maternal Germinal Trisomy 21 in Down Syndrome
It has now been over 50 years since it was discovered that Down syndrome is caused by an extra chromosome 21, i.e., trisomy 21. In the interim, it has become clear that in the majority of cases, the extra chromosome is inherited from the mother, and there is, in this respect, a strong maternal age effect. Numerous investigations have been devoted to clarifying the underlying mechanism, most rec...
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Objective: This study aimed to evaluate the quality of life and related factors in mothers of children with Down syndrome. Methods: The study method was correlation-survey (sectional). Sampling was based on the available population. The research population consisted of all mothers of children with Down syndrome referred to the Down Syndrome Center: out of them 70 mothers of chil...
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Introduction :Down syndrome is the most prevalent abnormal chromosomal disorder in human and the best known genetic cause of mental retardation which lays the foundations for physical and congenital defects and abnormalities. Abnormal behaviors of children with Down syndrome impair their mother's self-efficacy. The present study was conducted to investigate the effect of reality therapy on gene...
متن کاملVocal Parameters of Adults with Down Syndrome in Zahedan /Iran
Background & Aims: Previous studies have indicated significant differences in vocal parameters between children with Down syndrome and normal children, but there are challenges about these differences. In this study vocal parameters and Maximum Phonation Time (MPT) in adults with Down syndrome have been investigated. Method: This cross-sectional and analytic study was performed on 22 adults wit...
متن کاملStigma in Iranian Down Syndrome
Objectives: Stigma is a negative value. Many behaviors are to ward Stigmatized people. Down syndrome is one of conditions with Stigma. The aim of this study is to determine the sources of labeling in iranian Down syndrome. Methods: The View of 105 Down syndrome families concerning stigma were conducted. All of Down syndrome was under 50 years. Results: A fair proportion of Down syndrome f...
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ژورنال
عنوان ژورنال: BMC Genetics
سال: 2016
ISSN: 1471-2156
DOI: 10.1186/s12863-016-0412-3