Treatment of acute myeloid leukaemia with a triple cytotoxic regime: dat

The Effect of Monophosphoryl Lipid A on Maturation of DCs from Patients with Acute Myeloid Leukaemia

Background: Generation of monocyte-derived dendritic cells (MDDC) is induced in the presence of GM-CSF and IL-4, and a maturation stimulus is added to the monocyte culture to obtain mature Dendritic Cells (DCs) suitable for therapy. TNF-α is the most common cytokine used for activating DCs and generating mature MDDC either alone or in combination with other cytokines. Objective: To compare effe...

Razoxane in treatment of acute myeloid leukaemia.

Glutathione S-transferases Null Genotype in Acute Myeloid Leukaemia

Background: The glutathione S-transferase (GST) family of metabolising enzymes plays an important role in the detoxification of mutagens and carcinogens. The expression of many of these cancer susceptibility enzymes is genetically polymorphic. An increased frequency of GST-null genotypes has been associated with several malignancies. Objective: To investigate the rate of GSTT1 and GSTM1 null ge...

Treatment of acute myeloid leukaemia in a renal allograft recipient

cyclosporin may not greatly increase the toxicity ofaggressive chemotherapy used in the treatment of haematological malignancies. Sonneveld and Nooter reported a patient with resistent AML to whom they administered cyclosporin without any excessive toxicity, although their patient had profound marrow hypoplasia for three weeks.9 Septic shock is a well recognised problem in severely neutropenic ...

Diagnosis of Acute Myeloid Leukaemia

Acute myeloid leukaemia (AML) is a clonal, malignant disease of hematopoietic tissue characterized by accumulation of abnormal cells, mainly leukaemic blasts in bone marrow and impaired production of normal hematopoietic cells. Leukaemia was discovered in 1845, roughly at the same time by two doctors, Rudolph Virchow, a young Berlin pathologist and a Scottish pathologist, John Hughes Bennett. T...