Treatment of anthracycline extravasation from centrally inserted venous catheters

Complication rates among peripherally inserted central venous catheters and centrally inserted central catheters in the medical intensive care unit.

PURPOSE There are limited contemporary data describing the rates of catheter-related deep vein thrombosis (CRDVT) and central line-associated bloodstream infection for peripherally inserted central venous catheters (PICCs) and centrally inserted central venous catheters (CICCs) in the medical intensive care unit (ICU). METHODS We performed a retrospective cohort study of 200 PICCs (dual/tripl...

Treatment of anthracycline extravasation with dexrazoxane.

Accidental extravasation of anthracyclines is a feared complication. Present treatment consists of local cooling and extensive surgical debridement, which often results in severe morbidity. All clinically important anthracyclines are topoisomerase II poisons that are antagonized by topoisomerase II catalytic inhibitors such as dexrazoxane. Therefore, we investigated whether dexrazoxane protects...

Dexrazoxane treatment for intrathoracic anthracycline extravasation.

treatment of an intrathoracic epirubicin extravasation [3]. Approximately 140 mg of epirubicin extravasated into the pleural space when the tip of an implanted port catheter became misplaced. A pleural drain was inserted and the pleural cavity was immediately flushed with 1000 ml normal saline on 2 consecutive days. Dexrazoxane was also infused intravenously for the first three consecutive days...

Outcome of tunnelled central venous haemodialysis catheters inserted by radiologists.

Radiologists have only recently been involved in the percutaneous placement of tunnelled central venous haemodialysis catheters. We report our initial experience with our first 60 catheters. All catheters were successfully inserted. Immediate complications encountered included puncture site haemorrhage in 3 patients (5%) and puncture of the left brachiocephalic vein in 1 patient (1.7%). These w...

Potentially fatal complications of peripherally inserted central venous catheters (PICCs)