Trial of prophylactic mastectomy is needed

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Current status of prophylactic mastectomy.

The management of women at high risk for breast cancer presents a clinical dilemma to the health-care provider as well as to the woman herself. Current options include surveillance, prophylactic surgery (mastectomy and/or oophorectomy), and/or chemoprevention. Prophylactic mastectomy, including bilateral prophylactic mastectomy in high-risk women or contralateral prophylactic mastectomy in wome...

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How big is big enough? Thinking about contralateral prophylactic mastectomy.

When evaluating the benefit of a therapy, we must consider the effects of uncertainty and the magnitude of the gain or loss, having decided on a metric for outcome differences. With two alternatives (A and B) under consideration, there are three possible conclusions: Option A is substantially better; option B is substantially better; and the options are more or less equal—that is, the decision ...

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Contralateral prophylactic mastectomy: current perspectives

There has been an increasing trend in the use of contralateral prophylactic mastectomy (CPM) in the United States among women diagnosed with unilateral breast cancer, particularly young women. Approximately one-third of women <40 years old are undergoing CPM in the US. Most studies have shown that the CPM trend is mainly patient-driven, which reflects a changing environment for newly diagnosed ...

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Psychosocial Implications of Prophylactic Bilateral Mastectomy

Introduction: The removal of healthy breast tissue to prevent the development of breast cancer is seen by many to be a radical surgical intervention. As the numbers of women contemplating such surgery are increasing it is essential that the psychological costs and benefits of prophylactic bilateral mastectomy are established. Aims: This prospective study aims to measure psychological morbidity,...

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Perceptions of Prophylactic Mastectomy in Korea.

BACKGROUND Increasingly, prophylactic mastectomy has been evaluated as a treatment of breast cancer. Hereditary breast cancer now accounts for approximately 5%-10% of all cases of breast cancer, meaning that the widespread implementation of prophylactic mastectomy may significantly reduce the occurrence of breast cancer. However, prophylactic mastectomy is rarely performed in Korea. Therefore, ...

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ژورنال

عنوان ژورنال: BMJ

سال: 1999

ISSN: 0959-8138,1468-5833

DOI: 10.1136/bmj.318.7197.1556b