Triptolide, a HSP90 middle domain inhibitor, induces apoptosis in triple manner
نویسندگان
چکیده
منابع مشابه
Hsp90 inhibitor induces autophagy and apoptosis in osteosarcoma cells
Heat shock protein 90 (Hsp90) is constitutively expressed at 2‑10‑fold higher levels in tumor cells compared to normal cells, suggesting that it may be critically important for tumor cell growth and survival. These features make Hsp90 a potential target for anticancer drug development. Inhibition of Hsp90 activity not only results in rapid degradation of Hsp90 client proteins but also induces a...
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ژورنال
عنوان ژورنال: Oncotarget
سال: 2018
ISSN: 1949-2553
DOI: 10.18632/oncotarget.24737