Tumour necrosis factor in refractory asthma: new insight
نویسندگان
چکیده
منابع مشابه
Antagonism of tumour necrosis factor a in refractory asthma
Asthma that is refractory to treatment with inhaled corticosteroids affects 5–10% of patients with asthma; it is an important health and economic problem in the UK and most industrialised nations. It is estimated that J17.7 billion is spent on asthma healthcare per annum in Europe, of which a disproportionately large amount is attributed to patients with refractory asthma, on average six times ...
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Tumour necrosis factor-alpha (TNF-alpha) was measured by enzyme-linked immunosorbent assay and eosinophil cationic protein (ECP) by radio-immunoassay to evaluate TNF-alpha in nasal allergy. There was no significant difference either between the mean concentrations of TNF-alpha in nasal secretions from the patients with perennial nasal allergy and those of normal subjects, or between the TNF-alp...
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Many biological functions are regulated through interactions of extracellular molecules with their cognate cell surface receptors. The transduction of these signals by their receptors at the plasma membrane to the intracellular machinery results in such cellular activities as gene activation, protein phosphorylation, cell proliferation, and cell destruction. Though the kinetics of these activit...
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ژورنال
عنوان ژورنال: Thorax
سال: 2006
ISSN: 0040-6376
DOI: 10.1136/thx.2006.la0203