Two-pore domain potassium channels (K<sub>2P</sub>) in GtoPdb v.2023.1

The 4TM family of K channels mediate many the background potassium currents observed in native cells. They are open across physiological voltage-range and regulated by a wide array neurotransmitters biochemical mediators. pore-forming α-subunit contains two pore loop (P) domains subunits assemble to form one ion conduction pathway lined four P domains. It is important note that single do not have pores but each subunit has its primary sequence; hence name two-pore domain, or K2P (and channels). Some can heterodimers subfamilies (e.g. K2P3.1 with K2P9.1). nomenclature literature still mixture IUPHAR common names. suggested division into subfamilies, described More detailed introduction, based on similarities both structural functional properties within this explains "common abbreviation" tables below.