UK Chiari 1 Study: protocol for a prospective, observational, multicentre study

Introduction Chiari 1 malformation (CM1) is a structural abnormality of the hindbrain characterised by descent cerebellar tonsils through foramen magnum. The management patients with CM1 remains contentious since there are currently no UK or international guidelines for clinicians. We therefore propose collaborative, prospective, multicentre study on investigation, and outcome in UK: Study (UKC1S). Our primary objective to determine health-related quality life (HRQoL) new diagnosis managed either conservatively surgically at 12 months follow-up. also aim to: (A) HRQoL following surgery; (B) measure complications (C) natural history treated without (D) radiological correlates presenting symptoms, signs outcomes; (E) scope variation within practice referral patterns, patient pathways, investigations surgical decisions. Methods analysis UKC1S will be observational that follow British Neurosurgical Trainee Research Collaborative model collaborative research. Patients recruited after attending their first neurosurgical outpatient clinic appointment. Follow-up data collected from all baseline regardless whether they not. A further 12-month postoperative follow-up timepoint added decompressive surgery. expected last three years. Ethics dissemination received favourable ethical opinion East Midlands Leicester South Committee (REC reference: 20/EM/0053; IRAS 269739) Health Authority. results published peer-reviewed medical journals, presented scientific conferences, shared collaborating sites participant if so wish.