Ultraviolet : A Regulator of Immunity

[Ultraviolet: a regulator of immunity].

Humans establish acquired immune systems during the growth, which can sufficiently eliminate pathogen avoiding immune responses to self, such as allergy and autoimmunity. An imbalance of the acquired immune system leads up to immune-mediated disorders. Ultraviolet (UV) exposure helps to establish the normal peripheral tolerance to contact allergen avoiding excessive immune responses. By contras...

DYNAMIC SIMULATION OF A HIGH PRESSURE REGULATOR

In this paper, the dynamic simulation for a high pressure regulator is performed to obtain the regulator behavior. To analyze the regulator performance, the equation of motion for inner parts, the continuity equation for diverse chambers and the equation for mass flow rate were derived. Because of nonlinearity and coupling, these equations are solved using numerical methods and the results are ...

The Master Regulator of Immunity to Infection

Adenosine: an endogenous regulator of innate immunity.

Although inflammatory and immunological reactions protect the host from invasion by microorganisms and eliminate debris at sites of tissue injury, they can also be responsible for significant tissue damage. Thus, regulatory mechanisms that limit damage from an overly exuberant immune response have evolved. It is increasingly apparent that adenosine, a purine nucleoside that is elaborated at inj...

B7-H4 is a positive regulator of antitumor immunity.

B7-H4 (B7x, B7S1, VTCN1, DD-0110) is a member of the B7 superfamily that negatively regulates T cell responses.1 In addition, B7-H4 expression is increased on tumors and has been shown to be a negative prognostic marker for many cancers.2 Unexpectedly our recent study demonstrated that B7-H4 inhibited tumor growth and was required to promote effective antitumor responses.3.