Understanding Obscurin's Molecular Mechanisms
نویسندگان
چکیده
منابع مشابه
Understanding the molecular mechanisms driving metastasis
Metastasis continues to be a lethal hallmark of cancer, with most patients dying as a result of the dissemination of the disease to foreign organs rather than as a consequence of the primary tumor. Malignant cells spread from the primary tumor to distant sites, where they resist conventional treatments, proliferate, and cause failure of vital organs. Systemic dissection of the molecular, cellul...
متن کاملMolecular Mechanisms of Recurrent Pregnancy Loss
Introduction: Pregnancy and health is the process in which the egg is fertilized and being able to survive. When pregnancy occurs under some conditions and the fetus is being at risk, it will lead to abortion that occurs involuntarily and spontaneously. Abortions that occur more than two or three times are called recurrent pregnancy loss (RPL). Various etiological factors involved in RPL, inclu...
متن کاملUnderstanding the molecular mechanisms underlying complex cancer genome rearrangements
In their recent paper, Malhotra et al. performed a comprehensive analysis of the structural variation breakpoints in 64 cancer genomes from 7 tumor types to find the prevalence and origins of complex genomic rearrangements.1 Since this work represents a breakthrough in understanding of the molecular mechanisms underlying complex cancer genome rearrangements, we provide a brief overview of this ...
متن کاملRecent advances in understanding molecular mechanisms of primary afferent activation.
Thermal, mechanical, and chemical stimuli depolarise specialised damage sensing neurons to initiate electrical signals that may ultimately result in a sensation of pain. Over the past decade many of the receptors that transduce these signals have been identified by molecular cloning. In the absence of specific blockers, null mutant mice have proved valuable in exploring the function of these sp...
متن کاملTumour suppressor p53: understanding the molecular mechanisms inherent to cancer
Tumour suppressor p53 has been the centre of focus of researchers trying to decipher the molecular mechanisms underlying tumourigenesis. In this review, we have summarized the critical role of p53 in tumour suppression through its effects on several cellular processes such as DNA repair, cell cycle and apoptosis. We have also discussed the role of upstream regulators which sensitize p53 to resp...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2020
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2019.11.799