Universal Asymptotic Clone Size Distribution for General Population Growth

نویسندگان
چکیده

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Universal Asymptotic Clone Size Distribution for General Population Growth

Deterministically growing (wild-type) populations which seed stochastically developing mutant clones have found an expanding number of applications from microbial populations to cancer. The special case of exponential wild-type population growth, usually termed the Luria-Delbrück or Lea-Coulson model, is often assumed but seldom realistic. In this article, we generalise this model to different ...

متن کامل

Aortic Size Distribution in the General Population: Explaining the Size Paradox in Aortic Dissection.

BACKGROUND Current guidelines recommend a diameter of 5-5.5 cm as the threshold for surgery on the ascending aorta. However, a study from the International Registry of Acute Aortic Dissection showed that nearly 60% occurred at <5.5 cm (the 'aortic size paradox')--leading to a debate whether the size threshold should be lowered. However, the study showing dissection at small size had no knowledg...

متن کامل

Fluctuating fitness shapes the clone-size distribution of immune repertoires.

The adaptive immune system relies on the diversity of receptors expressed on the surface of B- and T cells to protect the organism from a vast amount of pathogenic threats. The proliferation and degradation dynamics of different cell types (B cells, T cells, naive, memory) is governed by a variety of antigenic and environmental signals, yet the observed clone sizes follow a universal power-law ...

متن کامل

Size Matters: Individual Variation in Ectotherm Growth and Asymptotic Size

Body size, and, by extension, growth has impacts on physiology, survival, attainment of sexual maturity, fecundity, generation time, and population dynamics, especially in ectotherm animals that often exhibit extensive growth following attainment of sexual maturity. Frequently, growth is analyzed at the population level, providing useful population mean growth parameters but ignoring individual...

متن کامل

Mono-Size Distribution Index (MSDI): A new criterion for the quantitative description of size distribution

Graphical size distribution is widely used in different fields of science and studies related to powders, droplets, bubbles, and pores. However, in some condition it may also be necessary to express the size distribution quantitatively. In spite of there being several suggested ways to quantify size distribution in the literature, some of these approaches are not applicable for many methods and...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Bulletin of Mathematical Biology

سال: 2016

ISSN: 0092-8240,1522-9602

DOI: 10.1007/s11538-016-0221-x