Universal Count Correction for High-Throughput Sequencing
نویسندگان
چکیده
منابع مشابه
Universal Count Correction for High-Throughput Sequencing
We show that existing RNA-seq, DNase-seq, and ChIP-seq data exhibit overdispersed per-base read count distributions that are not matched to existing computational method assumptions. To compensate for this overdispersion we introduce a nonparametric and universal method for processing per-base sequencing read count data called FIXSEQ. We demonstrate that FIXSEQ substantially improves the perfor...
متن کاملHiTEC: accurate error correction in high-throughput sequencing data
MOTIVATION High-throughput sequencing technologies produce very large amounts of data and sequencing errors constitute one of the major problems in analyzing such data. Current algorithms for correcting these errors are not very accurate and do not automatically adapt to the given data. RESULTS We present HiTEC, an algorithm that provides a highly accurate, robust and fully automated method t...
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ژورنال
عنوان ژورنال: PLoS Computational Biology
سال: 2014
ISSN: 1553-7358
DOI: 10.1371/journal.pcbi.1003494