Uremia impacts renal inflammatory cytokine gene expression in the setting of experimental acute kidney injury

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Uremia impacts renal inflammatory cytokine gene expression in the setting of experimental acute kidney injury.

Inflammatory cytokines are evoked by acute kidney injury (AKI) and may contribute to evolving renal disease. However, the impact of AKI-induced uremia on proinflammatory (e.g., TNF-alpha, MCP-1, TGF-beta1) and anti-inflammatory (e.g., IL-10) cytokine gene expression remains unknown. This study was undertaken to gain some initial insights into this issue. CD-1 mice were subjected to left renal i...

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ژورنال

عنوان ژورنال: American Journal of Physiology-Renal Physiology

سال: 2009

ISSN: 1931-857X,1522-1466

DOI: 10.1152/ajprenal.00381.2009