Uremic Toxins Induce THP-1 Monocyte Endothelial Adhesion and Migration through Specific miRNA Expression

Atherosclerosis is initiated by the activation of endothelial cells that allows monocyte adhesion and transmigration through vascular wall. The accumulation uremic toxins such as indoxyl sulphate (IS) p-cresol (PC) has been associated with atherosclerosis. Currently, miRNAs play a crucial role in regulation activation, adhesion, trans-endothelial migration. aim present study to evaluate effect IS PC on migration processes monocytes co-cultured well determine underlying mechanisms. incubation HUVECs THP-1 both resulted an increased migratory capacity cells. Furthermore, exposure upregulation BMP-2 miRNAs-126-3p, -146b-5p, -223-3p, nuclear factor kappa B (NF-κB) decrease its inhibitor IĸB. Uremic toxins, PC, enhance endothelium. These particularly contribute significantly uremia-associated disease increasing expression BMP-2, NF-κB, key development atherosclerotic diseases.