Urinary epidermal growth factor as a marker for lupus nephritis: clinical, laboratory, and histopathological study

Abstract Background Lupus nephritis can be seen in up to 60% of all SLE patients with 10–15% progressing end-stage renal disease; late diagnosis lupus is correlated a higher frequency insufficiency. The study aim determination the value urinary human epidermal growth factor (urinary EGF) as an early biomarker and its relevance disease activity histopathology. Results included 58 30 healthy controls; significant difference was noticed between controls protein, creatinine, protein/creatinine ratio, EGF. mean level EGF less classes IV V than I, II, III. There (33±29, 27±16, P = 0.04) class II III nephritis, no differences SLEDAI. On other hand, comparison showed not only 11.7±4.9 m, =0.003), but also SLEDAI (37.4±8, 70.5±27, 0.007), ratio (0.98±0.62, 3±1.8, =0.006). Conclusion This raises attention test sensitivity detecting subsequent changes pathology easy, non-invasive, accurate, cheap marker that could help following progression adjusting plan treatment; also, it used guide time biopsy or alternative cases where contraindicated.