Ursodeoxycholic acid unsaturates bile at a lower dose than chenodeoxycholic acid
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چکیده
منابع مشابه
Ursodeoxycholic acid, chenodeoxycholic acid, and 7-ketolithocholic acid are primary bile acids of the guinea pig.
Guinea pig gallbladder bile contains chenodeoxycholic acid (62 +/- 5%), ursodeoxycholic acid (8 +/- 5%), and 7-ketolithocholic acid (30 +/- 5%). All three bile acids became labeled to the same specific activity within 30 min after [3H]cholesterol was injected into bile fistula guinea pigs. When a mixture of [3H]ursodeoxycholic acid and [14C]chenodeoxycholic acid was infused into another bile fi...
متن کاملMucin in gall bladder bile of gall stone patients: influence of treatment with chenodeoxycholic acid and ursodeoxycholic acid.
The concentration of hexosamine, a marker for mucin, was determined and related to the degree of cholesterol saturation and to the occurrence of cholesterol crystals in gall bladder bile of gall stone patients (n = 40) and gall stone free subjects (n = 25). Ten of the gall stone patients had been treated with chenodeoxycholic acid (CDCA) and eight with ursodeoxycholic acid (UDCA) three to four ...
متن کاملEpimerization of chenodeoxycholic acid to ursodeoxycholic acid by human intestinal lec
Six strains of lecithinase-lipase-negative Clostridia, isolated from human feces, were capable of oxidizing chenodeoxycholic acid to 3a-hydroxy-7-keto-5P-cholanoic acid and of epimerizing it to ursodeoxycholic acid. The identity of the reaction products was confirmed by coniparing their mass spectra, obtained by combined gas-liquid chromatography-mass spectrometry, with those of authentic refer...
متن کاملIncreased formation of ursodeoxycholic acid in patients treated with chenodeoxycholic acid.
The formation of ursodeoxycholic acid, the 7 beta-hydroxy epimer of chenodeoxycholic acid, was investigated in three subjects with cerebrotendinous xanthomatosis and in four subjects with gallstones. Total biliary bile acid composition was analyzed by gas-liquid chromatography before and after 4 months of treatment with 0.75 g/day of chenodeoxycholic acid. Individual bile acids were identified ...
متن کاملEpimerization of chenodeoxycholic acid to ursodeoxycholic acid by human intestinal lecithinase-lipase-negative Clostridia.
Six strains of lecithinase-lipase-negative Clostridia, isolated from human feces, were capable of oxidizing chenodeoxycholic acid to 3 alpha-hydroxy-7 keto-5 beta-cholanoic acid and of epimerizing it to ursodeoxycholic acid. The identity of the reaction products was confirmed by comparing their mass spectra, obtained by combined gas-liquid chromatography-mass spectrometry, with those of authent...
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ژورنال
عنوان ژورنال: Gastroenterology
سال: 1978
ISSN: 0016-5085
DOI: 10.1016/0016-5085(78)93404-2