Usefulness of myocardial performance index in multiple sclerosis mitoxantrone-induced cardiotoxicity
نویسندگان
چکیده
منابع مشابه
Mitoxantrone-induced cardiotoxicity in patients with multiple sclerosis.
BACKGROUND There are few treatment options for patients with secondary progressive and worsening relapsing-remitting multiple sclerosis. Mitoxantrone is an antineoplastic drug, recently approved for treatment of multiple sclerosis. Mitoxantrone is, however, associated with dose-related cardiotoxicity, which limits its use. OBJECTIVE To investigate the possible cardiotoxicity of mitoxantrone i...
متن کاملSuppression of mitoxantrone cardiotoxicity in multiple sclerosis patients by dexrazoxane.
OBJECTIVE To explore the potential of dexrazoxane to suppress subclinical cardiotoxicity in MS patients receiving mitoxantrone. METHODS An open-label study was performed to evaluate possible subclinical cardiotoxicity in multiple sclerosis patients treated quarterly with mitoxantrone (48 mg/m(2) cumulative), with and without concomitant dexrazoxane, using blinded serial radionucleide ventricu...
متن کاملCardiotoxicity of Mitoxantrone Treatment in a German Cohort of 639 Multiple Sclerosis Patients
BACKGROUND AND PURPOSE The aim of this study was to elucidate the role of therapy-related cardiotoxicity in multiple sclerosis (MS) patients treated with mitoxantrone and to identify potential predictors for individual risk assessment. METHODS Within a multicenter retrospective cohort design, cardiac side effects attributed to mitoxantrone were analyzed in 639 MS patients at 2 MS centers in G...
متن کاملEarly onset cardiotoxicity associated with mitoxantrone in patients with multiple sclerosis.
M sclerosis (MS) is an autoimmune disease, involving predominantly the white matter of the brain and spinal cord. Approximately 85% of patients initially experience one or more relapses followed by complete or incomplete recovery; this clinical pattern is called the relapsing–remitting phase. Over 10 years, roughly 50% of these patients experience a transition to the secondary progressive phase...
متن کاملThe evaluation of doxorubicin-induced cardiotoxicity: comparison of Doppler and tissue Doppler-derived myocardial performance index.
BACKGROUND Doxorubicin is a chemotherapeutic agent used in a wide spectrum of cancers. However, cardiotoxic effects have limited its clinical use. The early detection of doxorubicin-induced cardiotoxicity is crucial. The purpose of our study was to assess values of Doppler and tissue Doppler imaging (TDI)-derived myocardial performance index (MPI) in adult cancer patients receiving doxorubicin ...
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ژورنال
عنوان ژورنال: Heart Asia
سال: 2012
ISSN: 1759-1104
DOI: 10.1136/heartasia-2012-010117