Using amplitude-phase parameters of circadian rhythms as diagnostic markers of carbohydrate metabolism disorders

BACKGROUND : With the development of visceral obesity, against background insulin resistance (IR), lipo- and glucose toxicity in tissues progresses, which disrupts metabolic balance body, is main factor type 2 diabetes mellitus (DM2). To date, a growing number publications highlighting role circadian rhythms control gluconeogenesis lipogenesis. In context DM2, process rhythm mismatch (desynchronosis) increasingly mentioned, for diagnosis calculation amplitude-phase parameters used. Thus, study disturbances using factors influencing them particular interest individuals with obesity prediabetes, since data obtained can be used as markers preclinical DM2. AIM identify significant differences (amplitude, acrophase) (fasting glycemia, basal body temperature, heart rate) desynchronosis groups without carbohydrate metabolism disorders, but presence prediabetes (impaired fasting impaired tolerance test) DM2 obesity. MATERIALS AND METHODS The was conducted well or disease experience not more than 5 years.In accordance design, every 3 hours during day, participants made self-measurements blood at home (using individual glucometers), temperature (BTT) armpit mercury thermometer) rate (HR) ( help an electronic tonometer), fixation results self-control diaries. assess reliability studied indicators, interpretation chronobiological (MESORa-Midline Estimating Statistic Rhytm; amplitude; carried out single сosinor analysis. RESULTS Of 120 participants, 73% were women 27% men. Mean age 58.6[52.2;56.7] years, BMI 31.3[29.7;33.9] WC 100 [93.8;104.7]. When conducting cosinor analysis, daily physiological indicators BTT differ from normal already group disorders form decrease amplitude (p<0.001), shift their acrophases (p <0.001), no dynamics night BBT (р<0.001). CONCLUSION Integral rate), desynchronosis, will have preventive focus. This method chronodiagnostics useful health prevention centers people risk developing