Using Change in the National Institutes of Health Stroke Scale to Measure Treatment Effect in Acute Stroke Trials

Using change in the National Institutes of Health Stroke Scale to measure treatment effect in acute stroke trials.

BACKGROUND AND PURPOSE Outcome measures in acute stroke trials are being refined. Changes in neurological deficits might be useful outcome measures because they can measure the entire spectrum of deficits. METHODS We analyzed data from the acute stroke treatment trial Trial of Org 10172 in Acute Stroke Treatment (TOAST). Using logistic regression analysis, we modeled the probability of the TO...

National Institutes of Health Stroke Scale (NIHSS).

Comparison of the National Institutes of Health Stroke Scale with disability outcome measures in acute stroke trials.

BACKGROUND AND PURPOSE Acute stroke trials typically use disability scales as their primary end point. Neurologic impairment scales such as the National Institutes of Health Stroke Scale (NIHSS) are possibly more sensitive to change in patient status. We aimed to compare a range of potential NIHSS end points with modified Rankin Scale (mRS) and Barthel Index (BI) end points. METHODS We simula...

What change in the National Institutes of Health Stroke Scale should define neurologic deterioration in acute ischemic stroke?

BACKGROUND Neurologic deterioration (ND) occurs in one-third of patients with stroke. However, the true incidence of ND and risk for adverse outcomes remains unknown because no standardized definition of ND exists. Our study compared the prognostic value of a range of definitions for ND in patients with acute ischemic stroke (AIS). METHODS All patients who presented to our center with AIS wit...

The effect of statins on National Institutes of Health Stroke Scale (NiHSS) in Ischemic stroke

Introduction. Stroke is a type of nervous focal disorder that occurs suddenly because of acute vascular events. 113-149 out of 100000 persons (0.113-0.149%) face with stroke in Iran annually. This causes treatment costs and many disabilities. Recently, studies indicated that statins, as a class of drugs, could decrease the chance of stroke recurrence and probably disabilities after stroke onset...