Utilization of complement receptors in immune cell–microbe interaction

analyzing patterns of classroom interaction in efl classrooms in iran

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A full complement of receptors in immune complex diseases.

In this issue of the JCI, Shushakova et al. (1) describe experimental results that provide a direct link between the C5a anaphylotoxin and the IgG Fc receptors (FcγRs) in mediating immune complex–triggered (IC-triggered) inflammatory disease. Using a murine lung model of IC-induced inflammation, the authors demonstrate that C5a, acting through the C5a receptor (C5aR), exacerbates inflammation i...

Immune Environment in a B Cell Complement Receptors

Complement Receptors in Inflammation

Complement was first discovered in 1889 as a bactericidal protein, distinct from heat stable antibodies present in normal serum. Since that time, it has been shown that the complement system is a biochemical cascade, comprised of more than 30 fluid phase and membraneassociated proteins, normally present as inactive forms. The complement system can be activated by different sequential cascades o...

Complement receptors 1 and 2 influence the immune environment in a B cell receptor-independent manner.

The CD21/35 proteins are complement receptors implicated in controlling and interpreting activation states of the innate and acquired immune responses. One defect of CD21/35(-/-) animals is depressed production of Ag-specific IgG3 which we show is evident in vivo but not in vitro. Gene expression profiles obtained from naive wild-type and CD21/35(-/-) splenocytes demonstrated enhanced expressio...