Utilizing Machine Learning to Accelerate Automated Assignment of Backbone NMR Data
نویسندگان
چکیده
منابع مشابه
Automated Assignment of Backbone NMR Data using Artificial Intelligence
Nuclear magnetic resonance (NMR) spectroscopy is a powerful method for the investigation of three-dimensional structures of biological molecules such as proteins. Determining a protein structure is essential for understanding its function and alterations in function which lead to disease. One of the major challenges of the post-genomic era is to obtain structural and functional information on t...
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Error tolerant backbone resonance assignment is the cornerstone of the NMR structure determination process. Although a variety of assignment approaches have been developed, none works well on noisy automatically picked peaks. We have designed an integer linear programming (ILP) based assignment system (IPASS) for this purpose. In order to reduce size of the problem, IPASS employs probabilistic ...
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ژورنال
عنوان ژورنال: American Journal of Undergraduate Research
سال: 2016
ISSN: 1536-4585,2375-8732
DOI: 10.33697/ajur.2016.005