Utilizing the information content in two-state trajectories
نویسندگان
چکیده
منابع مشابه
Utilizing the information content in two-state trajectories.
The signal from many single-molecule experiments monitoring molecular processes, such as enzyme turnover by means of fluorescence and opening and closing of ion channel through the flux of ions, consists of a time series of stochastic "on" and "off" (or open and closed) periods, termed a two-state trajectory. This signal reflects the dynamics in the underlying multisubstate on-off kinetic schem...
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15 صفحه اولToolbox for analyzing finite two-state trajectories.
In many experiments, the aim is to deduce an underlying multisubstate on-off kinetic scheme (KS) from the statistical properties of a two-state trajectory. However, a two-state trajectory that is generated from an on-off KS contains only partial information about the KS, and so, in many cases, more than one KS can be associated with the data. We recently showed that the optimal way to solve thi...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2006
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0604546103