'Validation' in genome-scale research

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'Validation' in genome-scale research

The individual 'validation' experiments typically included in papers reporting genome-scale studies often do not reflect the overall merits of the work.

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Comment ‘Validation’ in genome-scale research

Following the advent of genome sequencing, the past decade has seen an explosion in genome-scale research projects. Major goals of this type of work include gaining an overview of how biological systems work, generation of useful reagents and reference datasets, and demonstration of the efficacy of new techniques. The typical structure of these studies, and of the resulting manuscripts, is simi...

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Genome-Scale Validation of Deep-Sequencing Libraries

Chromatin immunoprecipitation followed by high-throughput (HTP) sequencing (ChIP-seq) is a powerful tool to establish protein-DNA interactions genome-wide. The primary limitation of its broad application at present is the often-limited access to sequencers. Here we report a protocol, Mab-seq, that generates genome-scale quality evaluations for nucleic acid libraries intended for deep-sequencing...

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Research Ethics: Validation of A Model for Factors Affecting Research Misconduct in Iranian Medical Research

Background: Designing a comprehensive model for verified relationships based on the actual tested data can help to better understand and explain the factors affecting research misconduct. The purpose of this study is to validate the model for factors affecting research misconduct in Iranian medical research. Method: This is a descriptive correlational study. The statistical population consiste...

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Construction and Validation of Emotional Divorce Scale in Iranian Population

Objective: Divorce is one of the social problems and underlying factors of many psychological problems, thereby demanding necessary research to prevent its occurrence. This study aimed to construct and validate Emotional Divorce Scale in Iranian couples.  Methods: This was a cross-sectional research. A total number of 400 married individuals living in east part of Tehran City, Iran between May...

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ژورنال

عنوان ژورنال: Journal of Biology

سال: 2008

ISSN: 1475-4924

DOI: 10.1186/jbiol104